产品货号：
Z31579
中文名称：
CDK2抗体
英文名称：
Anti-CDK2 Antibody (Clone#1534CT665.36.16)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CDK2 Antibody (Clone#1534CT665.36.16) |
| 指标别名 | CDK2;Cell division protein kinase 2;cyclin dependent kinase 2;p33 protein kinase;p33(CDK2) |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | CDK2 |
| 克隆号 | 1534CT665.36.16 |
| 抗体来源 | Mouse |
| 免疫原 | This CDK2 antibody is generated from a mouse immunized with protein from human CDK2. |
| 计算分子量 | 34kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Serine/threonine-protein kinase involved in the control of the cell cycle;essential for meiosis,but dispensable for mitosis.Phosphorylates CTNNB1,USP37,p53/TP53,NPM1,CDK7,RB1,BRCA2,MYC,NPAT,EZH2.Interacts with cyclins A,B1,B3,D,or E.Triggers duplication of centrosomes and DNA.Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis,and modulates G2 progression;controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation,and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus.Crucial role in orchestrating a fine balance between cellular proliferation,cell death,and DNA repair in human embryonic stem cells (hESCs).Activity of CDK2 is maximal during S phase and G2;activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition,and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis,the G2 phase.EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing.Phosphorylates CABLES1 (By similarity).Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC.Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis;regulates homologous recombination-dependent repair by phosphorylating BRCA2,this phosphorylation is low in S phase when recombination is active,but increases as cells progress towards mitosis.In response to DNA damage,double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation.Phosphorylation of RB1 disturbs its interaction with E2F1.NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes,thus initiating centrosome duplication.Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT- mediated activation of histone gene transcription during S phase.Required for vitamin D-mediated growth inhibition by being itself inactivated.Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner.USP37 is activated by phosphorylation and thus triggers G1-S transition.CTNNB1 phosphorylation regulates insulin internalization. |
| Uniprot ID | P24941 |
相关搜索：CDK2抗体，CDK2单抗，Anti-CDK2 Antibody (Clone#1534CT665.36.16)